Coding

Part:BBa_K5057005:Design

Designed by: Jan Zielinski   Group: iGEM24_Freiburg   (2024-09-06)


CONGA Q7 antimicrobial peptide


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


Design Notes

In the research article by Ghimire et al. (2023), the effect of of d-CONGA-Q7 was investigated by addition of the peptide extracellulary to diverse bacterial cultures. Therefore, it is plausible that the peptide interferes with the bacterial outer membrane or the bacteria itself from the outside. Therefore, it is reasonable to integrate the peptdie sequence with an extracellular localization sequenc


Source

The continued synthetic molecular evolution of d-CONGA-Q7 (d-amino acid CONsensus with Glycine Absent) as a new lineage of host-compatible antimicrobial peptides was descirbed by Ghimire et al. (2023)

References